Masterpieces of Italy Tour: From David to The Last Supper

View of Piazza Venezia in Rome, Italy

What to expect on this itinerary

Italy is like a treasure chest brimming with art, architecture, and innovation. Experience artistic brilliance with insightful guides accompanying you on an Italy tour personalized to your favorite inspirational masterpieces. Medieval villages overtake hillsides. Ancient arenas continue to permeate the skyline. Frescoes and mosaics retain their bright colors and continue to tell stories through the ages. From Rome to Milan, Florence to Venice, the masters of Italy crafted detailed works that have withstood the tests of time, filling every moment of your luxury Italian tour with a wealth of excellence, wonder, charm, and prestige.

Countries Visited

Italy, Vatican City

Places Visited

Rome, Vatican City, Florence, Assisi, Padua, Venice, Milan

Suggested Duration

10 Days

Customizable Itinerary

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Day 1

Rome – Arrive the Eternal City with a Fascinating Walking Tour and Dinner

Rome represents the brilliance of the classical era and the importance of artistry to daily life beyond the emperors and senators of the empire. Delicate and dramatic frescoes decorate churches. The Spanish Steps shimmer with opulent marble and elegant design. The dome of the Pantheon has inspired architects and artists for two millennia, including the legendary Michelangelo and Brunelleschi. Your flight lands at Rome Fiumicino Airport. Your private transfer greets you upon your arrival and escorts you to a gorgeous hotel in the historical city center. Locals and visitors wander along the designer shops along Via del Corso.

The scent of strawberries drifts out of a gelaterie, emanating from the fruity gelato. You take a moment to settle into the comforts of your luxury hotel set inside a former magnificent palace. Your guide greets you in the lobby, eager to introduce you to the masterful works of Rome on a walking tour through the city center. Consider learning more about the top Italy travel agents who will help design, create, and guide your dream Italy vacation. You can see the golden façade of Castel Sant’Angelo across the bridge over the Tiber River. The structure began as a mausoleum for Emperor Hadrian and was converted into a papal fortress centuries later. The 10 angelic statues line the cobblestone bridge, each designed with a careful eye to detail by master sculptor Bernini. His work guides your exploration of the city center, as you make your way to Piazza Navona to view the elaborate Fountain of the Four Rivers, which Bernini also designed.

What's Included:

Transfer
Accommodation
Tour
Day 2

Rome – Enjoy the Rich History of Rome on a Private Guided Full Day Tour

Day 3

Rome – Visit Vatican City and the Remarkable Churches Decorating Rome

Day 4

Florence – Wander Historic of Assisi and Enjoy a Fabulous Tour of Florence

Day 5

Florence – Explore the Uffizi, Pitti Palace, and Hidden Artisan Workshops

Day 6

Florence – Discover the Accademia, San Marco Church, and Central Market

Day 7

Venice – Relish the Churches and Cuisine of Bologna and Art of Padua

Day 8

Venice – Absorb the Art and Architecture on a Full Day Tour of Venice

Day 9

Milan – Venture to Milan to View the Duomo and Santa Maria delle Grazie

Day 10

Milan – Depart for Home

Trip Highlights

  • Discover the brilliance of Italian masters up-close and in person under the instruction of expert guides in art history, culture, and style
  • Visit the Vatican Museum to stand beneath the iconic images draping over the walls and ceiling as painted by Michelangelo in the 16th century
  • Trace the evolution of sculpture in Florence to enjoy the masterful works carved out of marble, including standing beneath Michelangelo’s David
  • Revel in the feeling of grandeur and amazement as you stand in front of Leonardo da Vinci’s masterpiece The Last Supper in Santa Maria delle Grazie
  • Witness the beginnings of the Renaissance while visiting the Scrovegni Chapel in Padua, where Giotto first applied human characteristics upon divine figures
  • Wander the galleries of Villa Borghese, home to one of the greatest private collections of art
  • Traverse the fabulous halls of the Accademia in Venice in search of the fabled Venetian masters inside the galleries in which they studied
  • Relish the unique ambiance of great Italian cities whose architecture is as masterful as the artwork which they contain 

Detailed Description

The masters of Italian art have shaped history through the way they captured allegories, biblical tales, and daily life. Your personalized Italy tour immerses you in the artworks of the past on a 10-day tour highlighting masterpieces, from the Colosseum to the Trevi Fountain, David to the frescoes in the Scrovegni Chapel. The thrilling exploration begins with your arrival in Rome. Your private transfer greets you at Fiumicino Airport and escorts you to a gorgeous hotel within the historical city center. Discover the iconic fountains and piazzas of the city with a private guide and explore the ancient architecture and preserved walkways winding between the Forum and Palatine Hill. Witness the elaborate collection of works inside the Vatican Museum, including works of Raphael and Michelangelo. Stroll through the elaborate galleries of the Borghese Villa to view one of the world’s most elaborate private art collections.

Visit the town of Assisi, in Umbria to follow in the footsteps of St. Francis. The basilica remains a dramatic piece of architecture home to fascinating frescoes and the antique tomb of the eponymous saint. Once in Florence, the images of the Renaissance spring to life. Enjoy a walking tour of the city’s endless wealth of structures designed by master architects, from the Medici chapel at San Lorenzo to the idyllic dome of the cathedral at the heart of the historic center crafted by Brunelleschi. Visit the masterpieces housed in the Uffizi and Pitti Palace before meeting with contemporary artisans preserving the traditions of quality goods handcrafted in Florence. Explore the Central Market for an enriching, flavorful experience and follow the historic evolution of sculpting in Florence, reaching the pinnacle with Michelangelo’s David.

Bologna is a city regarded for its cuisine but retains elements of masterful artwork and architecture on display around the city center. Stop in the quiet city of Padua en route to Venice to see Giotto’s masterworks decorating the Scrovegni Chapel, which various artists attribute bringing in the birth of the Renaissance. Venice is a city of grandeur embodied in the gorgeous palazzos and charming neighborhoods. Enjoy the graceful ambiance with tours of the Accademia Gallery and churches embedded with historical artwork, including St. Mark’s Basilica. You reach the marvels of Milan for a guided tour to take in the magnificent cathedral and The Last Supper by da Vinci. Your private transfer escorts you to Malpensa Airport on the final day of your Italy tour with plenty of time to check into your flight home.

Consider browsing our other Italian tours to gain further inspiration in perfecting your own dream Italy vacation of a lifetime. 

Starting Price

$4,500 per person (excluding international flights)

Your Zicasso trip is fully customizable, and this sample itinerary is a starting place for your travel plans. Actual costs are dynamic, and your selection of accommodations and activities, your season of travel, and other such variables will bring this budget guideline up or down. Throughout your planning experience with your Zicasso specialist, your itinerary is designed around your budget. You can book your trip when you are satisfied with every detail. Planning your trip with a Zicasso travel specialist is a free service.

What's Included

  • Accommodations
  • In-country transportation
  • Some or all activities and tours
  • Expert trip planning
  • 24x7 support during your trip

Your final trip cost will vary based on your selected accommodations, activities, meals, and other trip elements that you opt to include.

4.9

Verified Traveler Reviews

Based on 6185 reviews

Maria S.
Italy Trip Review: Ciociaria, 2-Week Trip

Our trip to Italy was absolutely amazing. Zicasso’s travel company provided exceptional service and attention to detail. We had never used a travel company for arrangements prior to this trip and we are so glad we did. It made the trip stress-free and truly over-the-top.

Our favorite time on the trip was at a location recommended by our travel agent in a very small area called Ciociaria. We loved this location and our resort in Ciociaria. The staff was incredible and we felt so relaxed.

I have been telling all my family and friends about the travel company’s services and that I will use them for future trips. I am so thankful to Zicasso for connecting me to an incredible experience with our travel company.

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Andrew A.
Italy Family Vacation Review: Rome, Florence, Mount Vesuvius, Wine Tasting, 10 Days

This was our first time using a travel agency for a trip like this and Zicasso’s travel company completely exceeded our expectations. Traveling internationally with pre-teen children can be stressful, but from the very beginning, this travel company removed every bit of that anxiety. Every detail was thoughtfully planned, clearly communicated, and flawlessly executed.

From airport transfers to hotels, tours, trains, guides, and daily logistics, everything worked seamlessly. We never once felt lost, rushed, or unsure of what was next. Instead of worrying about schedules or navigating a foreign country, we were able to fully focus on our family and enjoy the experience. That peace of mind alone was invaluable.

What really stood out was how well the trip was tailored to our family. The pacing was perfect, the experiences were engaging for adults and kids, and every guide we worked with was knowledgeable, friendly, and professional. It truly felt like a curated, high-quality experience rather than a generic itinerary.

We came home with incredible memories and zero travel stress, something I didn’t think was possible with kids that age. This travel company was phenomenal and we would absolutely use them again, and recommend them without hesitation to anyone considering international travel, especially families.

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Michael E.
Italy Vacation Review: Venice, Florence, Rome, Sorrento, Murano, Burano, Pisa, Vatican, Colosseum, Pompeii, Capri, Private Tours, Cooking Class, 10 Nights

I apologize for the delay in writing this review, but was very busy the last few months and wanted to dedicate the time it deserved. This review will address my wife and my trip to Italy from September 26, 2025, to October 6, 2025. Please feel free to share all or any portion of this review.

Trip Planning:

As a bucket-list event, I spent a great deal of time doing research, but would not have been able to put together the ideal vacation without the support of Zicasso and the travel company. Upon hearing my general interests, Zicasso provided two groups whom they thought would be able to plan and implement my trip. Both groups interviewed me and my wife about interests and price range, and then prepared an initial itinerary. Both groups would have done a fantastic job by their presentation, but it seemed I was slightly more in tune with the travel company and selected them. This proved to be a very wise choice, as the entire team at the travel company, particularly the travel specialists, were the absolute best and I would recommend their service without reservation. Fully responsive to my many questions before the trip, addressing all potential itinerary changes, and providing invaluable guidance throughout the entire process. Their response to inquiries while in the country was unbelievably prompt and thorough. At our request, the travel specialists made restaurant recommendations and reservations that were spot-on. I can’t say enough good things about these ladies.

Transportation and travel between locations:

Although not involved in the flights, the travel specialists provided great guidance concerning flights, trip insurance, and other logistics.

One key point that I fully expressed was that I did not want to flounder at the various transportation points and did not want to lug luggage in foreign areas on the way to and from lodging. The team took this to heart and provided me with either an escort or driver to and from every terminal. Everyone providing this task was friendly and provided information that made the travel much easier. Particularly valuable were our escorts, who adeptly negotiated our entrance and exit from Venice, and provided great insights into this historic city.

Venice:

Our hotel in Venice seemed to be right in the middle of everything, which allowed us to explore, and we have never had so much fun getting lost. At night, we opened our windows and fell off to sleep listening to nearby music; it was idyllic. The staff was professional and friendly. Breakfast was the best of all the hotels we stayed at in Italy.

The first full day in Venice, the travel company leveraged “skip the line” so we could make the very most of our time and is essential to any planning. Both guides were great and really good company. One guide’s knowledge of the Doge Palace really brought it to life for us. Another guide had a real insider’s view of Burano, as this was her family’s island. As private tours, we could go at our own pace, which we really liked. Probably the least enjoyable tour was the glass factory in Murano. We got the impression most of the tour beyond the initial exhibition was an attempt to sell their products. My wife succumbed and purchased a pair of earrings that broke the first time she wore them. Really disappointing, and I would advise you to spend more time in Burano.

Florence:

As with all the trains, the travel was very comfortable and we enjoyed watching the scenery. Our lodging in Florence was right on the Santa Maria square, superb for people watching. The staff was fine, nothing more. The hotel was near the world’s oldest pharmacy, famous as the world's oldest perfumery. Although there is a line to enter, it goes quickly and is historical, to say nothing of buying a scent more than 400 years old. I strongly recommend you go.

While knowledgeable, our tour guide for the Accademia and Uffizi Galleries was a little too technical for us, leaving us with the feeling that we were taking an art history class.

Dinner was based on the travel specialist's recommendation and it was delicious. A strong recommendation.

Day trip to Pisa:

The travel arrangements were perfect. The purpose of the trip was to take the obligatory picture holding up the tower—hokey, but we loved it.

The private cooking class with our instructor was a lot of fun. The view of the city from her window at sunset was beautiful. My wife and our instructor fell into a real rhythm cooking, and she was kind enough not to scoff at my ham-handed attempts. Her directions were simple enough for me to follow, theoretically. She followed up her lesson with an email containing detailed recipes. We have purchased all necessary utensils and are planning a pasta-making party soon. This was a fun change of pace.

Rome:

Our bed-and-breakfast in Rome was our least favorite lodging. Entry into the building was confusing and, as a B&B, the desk was not manned all the time, which made it difficult to secure a taxi early in the morning (we had to walk to a nearby hotel) or get assistance after 8pm or before 6am. When we came in, we attempted to coordinate laundry service with the person working the front desk, followed his instructions, but when we returned the next day, our dirty clothes were still where we were told to leave them. The initial response from the on-duty staff, who I believe was the owner, was that the individual was no longer an employee. Ultimately, the hotel comped and completed our laundry, which was nice. We would have preferred different lodging.

Our first afternoon, we took a four-hour golf cart tour, which was our favorite tour of the entire trip. Adding an extra hour to the traditional length and having only my wife and me allowed us to do everything we wanted to do. Our driver took us everywhere. He would drop us at the top of the Spanish Steps and meet us at the bottom, and would conveniently bring us closest to all other locations. I can’t believe how much we did in four hours. Our driver brought all these iconic sites to life with his marvelous insight and provided a great insider view of these monuments. This is a must-do for all first-time visitors to Rome. The only thing we were not able to do, due to no fault of our driver, was the Aventine Keyhole. When we got there in the afternoon, the line was 45 minutes and not a wise use of our time. If this is a strong interest, he recommends going early in the morning.

The travel specialists arranged tickets for the Papal general audience on Wednesday. Rising at sunrise was worth it to get the seats as close as we were able to secure. Most online sites suggest getting there an hour and a half before the start time, but I think that is much too late. I recommend you get there three to four hours ahead to get the best seats. The best seats are on the end near where the Pope drives by, ideally near an infant, and His Holiness will stop to personally bless these children. Facing the stage, the right side filled up quicker than the left side, so go directly to the left side of the audience. Being so close to the first American-born Pope was a memory I will never forget. His Holiness blesses all items in the audience's possession, so load up on rosary beads; they will make great Baptism and Communion gifts.

The afternoon was our first group tour at the Vatican Museums. It might be that we were spoiled with the previous private tours, but linking up with the group was chaotic and the quality of the tour was contingent on those in our group. Fortunately, all our groups were good, considerate, and friendly people. The main value was skipping the line for entrance. As with the Doge Palace, our guide was a little too academic and didn't really manage time well, potentially a victim of being in a group, but I would have rather spent more time in the Sistine Chapel and the Basilica. Taxis were extremely hard to get back to the hotel and I would arrange a ride if I were to do it again.

The Thursday tour of the Colosseum and Forum was also a group tour, but led by a guide who brought this ancient land to life. An archaeologist by trade, our guide seemed to know everything and also took a great picture.

The end of a very long but enjoyable day was another group tour of the catacombs and Santa Maria Maggiore. While the catacombs were the main attraction, the after-hours and behind-the-scenes access to Santa Maria Maggiore was an unexpected gem. Going through a second Holy Door, viewing the magnificent nighttime skyline from the roof, seeing the location of a relic from the baby Jesus’ manger, and being struck by the modesty of Bernini’s and Pope Francis’s tombs were all highlights. Unfortunately, taxis were again hard to come by.

Sorrento:

We took a train from Rome to Naples. While there was a national strike, it did not prove more than an inconvenience, no worse than New York City on a regular day. Our driver from Naples told us this simply provided us with a genuine Italian experience. I wish I could remember this driver’s name because he was the best of a very good group of drivers during this trip. En route to Sorrento, we stopped for a tour and meal at a winery and a private skip-the-line tour of Pompeii. We were so impressed with the quality of the winery that we made a large purchase of wines and olive oils that, thankfully, included free shipping.

During our drive to Sorrento, our driver took us through his hometown, which we really enjoyed. Going through the town, he pointed out the birthplace of Bruce Springsteen’s mother. Little did he know, we were from New Jersey and are HUGE Springsteen fans.

Our hotel in Sorrento was a nice place, close to the center of town. I would have preferred a hotel with a view of the coast.

On Saturday, we took a private tour up the coast. This was the most comfortable car I have ever ridden in, with heated and cooled seats, and a convenient icebox. The driver made clear he was at our disposal. The scenery was marvelous and it was a thrill to dip our toes in the Med. Our driver hooked us up with a restaurant on a cliff overlooking the water—beautiful and scrumptious.

Our last day was supposed to be the Gozzo tour of Capri, but was canceled due to weather. We refunded the canceled boat tour, but ate the driver and ferry fees. In hindsight, knowing this day was largely contingent on weather, I would have liked to have a contingency plan and would advise the travel company to plan this in the future.

Based on how smoothly things went, we will be contacting Zicasso to arrange a trip to Iceland and Ireland next fall, and hope they can refer a team as talented as this travel company.

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Susan F.
Italy Anniversary Trip Review: Rome, Orvieto, Siena, Montepulciano, Chianti, Florence, Bologna, Venice, Wine Tasting, Food Tour, 2 Weeks

Thank you to Zicasso’s travel specialist and her amazing staff. The itinerary was fabulous. It was filled with food, wine, and highlights of the most important tourist places. Her guidance throughout the year-plus planning was the right amount of checking in and waiting. Thank you for the nudges to have reservations for all the holiday days. Things seemed to be pretty open overall, but it was nice not to worry.

All the restaurants set up for us were wonderful. The app was terrific to keep track of what we were doing when. All the drivers were very friendly, professional, and punctual.

Thank you for making our 35th wedding anniversary trip (December 22 2024 to January 6 2025) a most memorable one. We hope to return to Italy to enjoy the southern area and maybe some of the beaches and islands.

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Mary J.
Italy Tour Review: 11 Nights

We had an excellent itinerary and we really liked the accommodations provided, and their locations within walking distance of our must-see sites.

Excellent tour guides, drivers, and transportation were provided!

The Zicasso travel expert's recommended restaurants were also great and the guidelines were helpful!

My husband and I saw and enjoyed what we needed to see and experience!

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Tracy S.
Italy Trip Review: Bike Tour, 5 Nights

It was a great experience! Every activity was fun and interesting. The guides and drivers were wonderful. You made our trip so easy.

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Customizable Itinerary

This is a sample itinerary to inspire a personalized trip designed with your travel specialist.

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