South America Wine Tour: Chile, Argentina and Uruguay

Vineyards and the Andes Mountains in Mendoza, Argentina

What to expect on this itinerary

In South America, there is magic in the wind, a stirring in the air, and a delicious glass of wine in your hand. There is history and culture, romance and passion, and the most decadent reds and delicate whites you’ve ever had. There is fine food and fine art, world-class museums and out-of-this-world scenery, and somewhere along the way, you realize: California and France have nothing like this.

Countries Visited

Argentina, Chile, Uruguay

Places Visited

Santiago, Mendoza, Colonia del Sacramento, Buenos Aires

Suggested Duration

10 Days

Customizable Itinerary

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Day 1

Santiago – Bienvenidos

Touch down this morning in stunning Santiago, where you can climb mountains in the morning and enjoy a sunset over the Pacific in the evening. You’ll be transferred by private car from the airport to your centrally located four-star hotel, where you’ll feel the vibrancy and joie de vivre of this remarkable city.  Take a moment to drop off your luggage and recover from your overnight journey, and then prepare for an amazing introduction.

Your tour of Santiago begins at its civic center, the heart of soul of this metropolitan marvel: the Plaza de Armas. Here, you’ll take in the astounding Metropolitan Cathedral of Santiago, a neoclassical masterpiece that dominates the eye with its elegance and grace. Visit the gorgeous Central Post Office building, whose façade gives off the inescapable luxury of the best-known cities of Europe. The Palacio de Real Audiencia is the former seat of the courts of justice. Continue on to La Moneda, where the Presidential Palace sits directly above the fascinating Centro Cultural Palacio de Moneda – one of the best places in the city to catch local artists and artisans plying their wares and honing their skills. Then, set out for Santa Lucia Hill, where the city was originally founded in the middle of the 16th century.

The tour ends with a stroll through some of the cities most unique and unforgettable districts. Bellavista offers a wide array of markets and fairs as well as a charmingly bohemian ambiance, while the residential neighborhoods of Vitacura, Las Condes, and Providencia showcase some of Santiago’s finest examples of architecture. In the evening, you’ll want to hit one of the city’s excellent jazz clubs – the Club de Jazz de Santiago is perhaps the city’s best, and it attracts some of the finest talents from around the world.

What's Included:

Transfer
Accommodation
Day 2

Santiago – An Introduction to Chile’s Bustling Wine Scene

Day 3

Mendoza – Crossing the Andes to Argentina

Day 4

Mendoza – The Fruits of Argentina’s Viticultural Regions

Day 5

Mendoza – A Day of Exploration in Western Argentina

Day 6

Colonia del Sacramento – Heading East to Uruguay

Day 7

Colonia del Sacramento – Discovering Uruguay’s Oldest City

Day 8

Buenos Aires – Making Your Way to Inimitable Buenos Aires

Day 9

Buenos Aires – Hitting the Highlights in Argentina’s Cosmopolitan Capital

Day 10

Buenos Aires – The End of Your Latin American Adventure

Trip Highlights

  • Discover the many charms of sensational Santiago, from the idyllic Santa Lucia Park, to the lively scene at the Plaza de Armas, to the enticing nightlife 
  • Enjoy the life of a gourmand in marvelous Mendoza, the center of Argentina’s wine country and the home to some of the finest restaurants, hotels and museums in the country
  • Explore the vineyards and wineries of South America, from the up-and-coming establishments that fill Chile’s Central Valley, to the established master craftsmen that work their magic in western Argentina
  • Visit beautiful Colonia del Sacramento, the oldest city in Uruguay and a UNESCO World Heritage Site since 1995, where the waters of the Rio de la Plata give way to a village that is as historic as it is charming
  • Experience all of the passion and grandeur of breathtaking Buenos Aires, from the tango dancers that fill the streets of La Boca, to the stately sophistication of Palermo and Recoleta, to the stretch of the Avenida 9 de Julio, the widest street on the planet

Detailed Description

From the rapid-fire Spanish that sings through the streets of Buenos Aires to the serenity of Colonia del Sacramento, to the unbeatable scenery that surrounds Santiago - Argentina, Uruguay, and Chile are three countries that cast an irresistible spell over locals and visitors alike. This 10-day tour will show you all the best that the Southern Cone has to offer, and is sure to inspire your imagination and delight all of your senses.

Begin in Santiago, where the blue waters of the Pacific give way to the craggy rises of the Andes, and where the history and culture fill the air from the highest peaks to the rolling surf. Journey on to Uruguay’s oldest city, Colonia del Sacramento, a stirring relic to the imperial desires of Spain and Portugal as well as the creative impulses of the Uruguayan people. Encounter the irresistible allure of Buenos Aires, where romance echoes from every street corner and where history is found in even the most seemingly mundane quarters. And, of course, spend some time at some of the best wine-growing regions of the world, from Concha y Toro in the fertile Chilean valleys to masterful Mendoza, the largest wine producer on the continent. This is a tour for culture lovers as well as wine lovers, and it’s one that you’re sure to remember for the rest of your life.

Starting Price

$4,100 per person (excluding international flights)

Your Zicasso trip is fully customizable, and this sample itinerary is a starting place for your travel plans. Actual costs are dynamic, and your selection of accommodations and activities, your season of travel, and other such variables will bring this budget guideline up or down. Throughout your planning experience with your Zicasso specialist, your itinerary is designed around your budget. You can book your trip when you are satisfied with every detail. Planning your trip with a Zicasso travel specialist is a free service.

What's Included

  • Accommodations
  • In-country transportation
  • Some or all activities and tours
  • Expert trip planning
  • 24x7 support during your trip

Your final trip cost will vary based on your selected accommodations, activities, meals, and other trip elements that you opt to include.

4.8

Verified Traveler Reviews

Based on 924 reviews

Argentina, Chile Tour Review: Perito Moreno, Los Glaciares, Atacama, Torres del Paine, Buenos Aires, Hiking, Cooking Class, 25 Days

My trip was an incredible adventure, which I feel fortunate to have experienced. The excursions were well chosen and hotels outstanding. The logistics of a long trip with over six destinations and activities in the desert, mountains, and urban areas were artfully arranged by Zicasso’s travel specialist and supported by vendors and transit agencies. I had a support network that allowed me to totally enjoy the beautiful and diverse environments, cultures, and activities.

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Argentina Tour Review: Buenos Aires, Iguazu, Bariloche, El Calafate, El Chalten, 2 Weeks

We take great pleasure in saying our Patagonian adventure through Zicasso and the tour operator was near perfect. Our sincere thanks to our travel specialist and everyone at the tour operator for the red-carpet treatment we received at every destination on our itinerary: namely Buenos Aires, Iguazú, Bariloche, El Calafate, and El Chalten. We commend everyone involved in the personalized communication, planning and execution of our two exciting weeks traveling throughout Argentina.

Beginning in December 2025, the travel specialist and his team worked out every detail of travel in Argentina's fall season: all our domestic flights, customized tours, airport transfers, and, most importantly, the most knowledgeable, engaging guides we could ever have imagined. We can't make enough positive comments about our first Patagonian adventure.

Every driver arrived promptly, putting us immediately at ease. Every evening, team members messaged us on WhatsApp to remind us of the next day's transfers and tours. They followed up immediately with answers to any questions we had.

All of our guides were exceptional. Their passion and depth of knowledge made our tours more fascinating and entertaining than any we've ever experienced. We could not have planned anything remotely close to the guides the tour operator included for each tour.

We will most assuredly utilize the services of the travel specialist at the best tour company we have ever found for adventures in South America.

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Chile, Argentina Trip Review: San Rafael Lagoon, Torres del Paine, Perito Moreno Glacier, Iguazu Falls, Glacier Walk, 19 Days

We had great hotels, great guides, great experiences, and great support via WhatsApp from Zicasso's travel specialists during the trip.

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Chile Travel Review: Santiago, Patagonia, Hiking, 1 Week

It was a very well-organized trip with a lot of attention to detail. The tour guides were professional and kind. I fell sick the first day in Santiago and the hotel staff were extremely helpful with organizing a doctor and helping me get appropriate medication in the middle of the night. Patagonia is a truly wonderful place and the arrangements were excellent. Thank you.

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Argentina, Chile Tour Review: Torres del Paine, 5 Nights

Zicasso’s travel specialist was very easy to work with and put together the unique itinerary that we were looking for. He was also very attentive to our needs during the trip. I would definitely recommend him and his company to anyone traveling to southern South America.

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Argentina, Chile, Vacation Review: Patagonia, Torres del Paine, Hiking, Glaciers, 1 Month

The trip was extremely well organized by Zicasso's travel specialist and a comprehensive tour of Patagonia. It included nature, history, wine, and culinary experiences. Great trip.

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Customizable Itinerary

This is a sample itinerary to inspire a personalized trip designed with your travel specialist.

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